Modifying Enzymes
New England Biolabs, Inc. Antarctic Thermolabile UDG – 100 units
Antarctic Thermolabile UDG (Uracil- DNA Glycosylase) catalyzes the release of free uracil from uracil-containing single-stranded or double-stranded DNA. The resulting abasic sites are susceptible to hydrolytic cleavage at elevated temperature and high pH. This enzyme is sensitive to heat and can be rapidly and completely inactivated at temperatures above 50C.
Worthington Biochemical Corporation PHOSPHODIESTERASE II 10UN
Prepared from the 1 mM sodium pyrophosphate, pH 6.9, alumina gel eluate of Hilmoe, Biochem. Prep, 8, (Meister, A., ed.), John Wiley & Sons, NY, NY, p. 105 (1961). Lyophilized in vials. 9068-54-6
Selleck Chemical LLC Cabozantinib (BMS-907351) 200mg 849217-68-1 XL184
Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM in cell-free assays, respectively. Cabozantinib induces PUMA-dependent apoptosis in colon cancer cells via AKT/GSK-3?/NF-?B signaling pathway. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
CAYMAN CHEMICAL 1-Oleoyl Glycerol 1g
A monoacylglycerol containing oleic acid at the sn-1 position; enhances diffusion of cyclosporin A from the donor compartment of a Franz diffusion cell into the stratum corneum, epidermis, and dermis of porcine EAr skin, as well as through the skin to the receptor compartment in a formulation with cyclosporin A in propylene glycol; mixed micellar systems with bile salts increases the Papp and absorption rate of amphotericin B in perfused rat intestine in vivo
Echelon Biosciences Research Labs BODIPY FL Phosphatidylinositol 50 ug
BODIPY FL Phosphatidylinositol is a water soluble analog of Phosphatidylinositol (PI) labeled with the green fluorophore, Bodipy-FL at the sn-1 position.Phosphoinositides (PIPns) are minor components of cellular membranes but are integral signaling molecules for cellular communication. Phosphatidylinositol (PI or PtdIns) is biosynthesized from CDP-diacylglycerol and inositol by phosphatidylinositol synthase. PI is the building block for phosphoinositide polyphosphates through phosphorylation by PI-kinases and is a substrate for PI-PLC yielding diacylgelycerol. This item is non returnable
Echelon Biosciences Research Labs ZN PROTOPORPHYRIN IX 100 mg
Zn (II) Protoporphyrin IX is an inhibitor of heme oxygenase (the enzyme that catalyzes the conversion of heme to biliverdin in the heme degradation pathway) and guanylyl cyclase. Heme oxygenase has been implicated in tumor cell resistance to chemotherapy, reduction of free radical formation and inflammation, and associated with vascular repair.h4>StorageZinc (II) Protoporphyrin IX is stable for at least one year when stored as a solid, protected from moisture, at -20 C. Protect from light. This item is non returnable